A Cascade of Morphogenic Signaling Initiated by the Meninges Controls Corpus Callosum Formation

@article{Choe2012ACO,
  title={A Cascade of Morphogenic Signaling Initiated by the Meninges Controls Corpus Callosum Formation},
  author={Youngshik Choe and Julie A Siegenthaler and Samuel J Pleasure},
  journal={Neuron},
  year={2012},
  volume={73},
  pages={698-712}
}
The corpus callosum is the most prominent commissural connection between the cortical hemispheres, and numerous neurodevelopmental disorders are associated with callosal agenesis. By using mice either with meningeal overgrowth or selective loss of meninges, we have identified a cascade of morphogenic signals initiated by the meninges that regulates corpus callosum development. The meninges produce BMP7, an inhibitor of callosal axon outgrowth. This activity is overcome by the induction of… CONTINUE READING
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