A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis

@article{Wilkins2014ACO,
  title={A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis},
  author={B. Wilkins and N. A. Rall and Yogesh B Ostwal and Tom Kruitwagen and Kyoko Hiragami-Hamada and M. Winkler and Y. Barral and W. Fischle and H. Neumann},
  journal={Science},
  year={2014},
  volume={343},
  pages={77 - 80}
}
  • B. Wilkins, N. A. Rall, +6 authors H. Neumann
  • Published 2014
  • Biology, Medicine
  • Science
  • Chromosome Condensation The forces that shape the structure of the highly condensed metaphase chromosomes seen during cell division in eukaryotes are still largely unknown. In vitro evidence suggests that the amino-terminal tails of the histones—such as interaction of the histone H4 tail with H2A-H2B—play an important role in chromosome hypercondensation. Wilkins et al. (p. 77) used ultraviolet cross-linker amino acids in the histones of bakers' yeast to show that during early mitosis… CONTINUE READING
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