A Carrier for Non-Covalent Delivery of Functional Beta-Galactosidase and Antibodies against Amyloid Plaques and IgM to the Brain

@inproceedings{Sarkar2011ACF,
  title={A Carrier for Non-Covalent Delivery of Functional Beta-Galactosidase and Antibodies against Amyloid Plaques and IgM to the Brain},
  author={Gobinda Sarkar and Geoffrey L. Curran and Eric W Mahlum and Teresa D Decklever and T. M. Wengenack and Anthony J Blahnik and Bridget Hoesley and Val J. Lowe and J. F. Poduslo and R. Brian Jenkins},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Therapeutic intervention of numerous brain-associated disorders currently remains unrealized due to serious limitations imposed by the blood-brain-barrier (BBB). The BBB generally allows transport of small molecules, typically <600 daltons with high octanol/water partition coefficients, but denies passage to most larger molecules. However, some receptors present on the BBB allow passage of cognate proteins to the brain. Utilizing such receptor-ligand systems, several investigators… CONTINUE READING

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