A Caries Vaccine?

  title={A Caries Vaccine?},
  author={Michael W. Russell and Noel K Childers and Suzanne M. Michalek and Daniel J. Smith and Martin A. Taubman},
  journal={Caries Research},
  pages={230 - 235}
Studies performed in numerous laboratories over several decades have demonstrated the feasibility of immunizing experimental rodents or primates with protein antigens derived from Streptococcus mutans or Streptococcus sobrinus against oral colonization by mutans streptococci and the development of dental caries. Protection has been attributed to salivary IgA antibodies which can inhibit sucrose-independent or sucrose-dependent mechanisms of streptococcal accumulation on tooth surfaces according… 

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toxin B subunit . with a bacterial protein antigen and the Cholera responses in monkeys immunized intranasally Salivary , nasal , genital , and systemic antibody

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Long-term persistence and recall of immune responses in aged mice after mucosal immunization.

The data show that aged mice retain the ability to mount immune responses to mucosally presented immunogens and that memory to mucOSally presented Immunogens can persist for almost the whole lifetime of a mouse.

Generation of Female Genital Tract Antibody Responses by Local or Central (Common) Mucosal Immunization

Analysis of the molecular form of genital IgA indicated that the majority of both total IgA and specific IgA antibody was polymeric, and likely derived from the common mucosal immune system.

An investigation into the mechanism of protection by local passive immunization with monoclonal antibodies against Streptococcus mutans

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Intranasal immunization of humans with Streptococcus mutans antigens.

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Passage of immunoglobulins from plasma to the oral cavity in rhesus monkeys.

The results suggest that intact molecules of IgG, IgA and IgM can pass from plasma to the oral cavity via crevicular fluid, and could contribute to oral defence mechanisms particularly in thecrevicular domain.

Ontogeny of immunity to oral microbiota in humans.

  • D. SmithM. Taubman
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  • 1992
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The finding that the GLU polypeptide alone, in the absence of any immunoenhancing agents, is protective against disease offers a promising and safe strategy for the development of a vaccine against caries.

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