A Caries Vaccine?

@article{Russell2004ACV,
  title={A Caries Vaccine?},
  author={Michael W. Russell and Noel K Childers and Suzanne M. Michalek and Daniel J. Smith and Martin A. Taubman},
  journal={Caries Research},
  year={2004},
  volume={38},
  pages={230 - 235}
}
Studies performed in numerous laboratories over several decades have demonstrated the feasibility of immunizing experimental rodents or primates with protein antigens derived from Streptococcus mutans or Streptococcus sobrinus against oral colonization by mutans streptococci and the development of dental caries. Protection has been attributed to salivary IgA antibodies which can inhibit sucrose-independent or sucrose-dependent mechanisms of streptococcal accumulation on tooth surfaces according… 

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