A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells
@article{Kogan2006ACQ, title={A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells}, author={Natalya M Kogan and Cristina Blázquez and Luis Álvarez and Ruth Gallily and Michael Schlesinger and Manuel Guzm{\'a}n and Raphael Mechoulam}, journal={Molecular Pharmacology}, year={2006}, volume={70}, pages={51 - 59} }
Recent findings on the inhibition of angiogenesis and vascular endothelial cell proliferation by anthracycline antibiotics, which contain a quinone moiety, make this type of compound a very promising lead in cancer research/therapy. We have reported that a new cannabinoid anticancer quinone, cannabidiol hydroxyquinone (HU-331), is highly effective against tumor xenografts in nude mice. For evaluation of the antiangiogenic action of cannabinoid quinones, collagen-embedded rat aortic ring assay…
68 Citations
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