A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice

@inproceedings{Steitz2010ACH,
  title={A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice},
  author={Julia Steitz and Peter G Barlow and Jaber Hossain and Eun Jung Kim and Kaori Okada and Tom Kenniston and Sheri L Rea and Ruben O. Donis and Andrea A. Gambotto},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND In 2009 a new pandemic disease appeared and spread globally. The recent emergence of the pandemic influenza virus H1N1 first isolated in Mexico and USA raised concerns about vaccine availability. We here report our development of an adenovirus-based influenza H1N1 vaccine tested for immunogenicity and efficacy to confer protection in animal model. METHODS We generated two adenovirus(Ad5)-based influenza vaccine candidates encoding the wildtype or a codon-optimized hemagglutinin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Similar Papers

Loading similar papers…