A Canadian multicenter, double-blind study of paroxetine and fluoxetine in major depressive disorder.

@article{Chouinard1999ACM,
  title={A Canadian multicenter, double-blind study of paroxetine and fluoxetine in major depressive disorder.},
  author={Guy Chouinard and B. S. Saxena and Marie Claire B{\'e}langer and Arun Ravindran and David Bakish and Linda Beauclair and Phillip Morris and N P Vasavan Nair and Ranjit Manchanda and R T Reesal and Ronald A. Remick and Matthew C O'Neill},
  journal={Journal of affective disorders},
  year={1999},
  volume={54 1-2},
  pages={39-48}
}
BACKGROUND Recent studies have suggested clinical differences among selective serotonin reuptake inhibitors. In a 12-week randomized, multicenter, double-blind trial, the antidepressant and anxiolytic efficacy of the selective serotonin reuptake inhibitors paroxetine and fluoxetine was compared in patients with moderate to severe depression. METHODS A total of 203 patients were randomized to fixed doses (20 mg/day) of paroxetine or fluoxetine for the first six weeks of therapy. From week 7-12… CONTINUE READING

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