A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress.

@article{Arkblad2005ACE,
  title={A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress.},
  author={Eva Lagberg Arkblad and Simon Tuck and Nikolay B. Pestov and Ruslan I Dmitriev and Maria B Kostina and J{\"o}rgen Stenvall and Mattias Tranberg and Jan Rydstr{\"o}m},
  journal={Free radical biology & medicine},
  year={2005},
  volume={38 11},
  pages={1518-25}
}
Proton-translocating mitochondrial nicotinamide nucleotide transhydrogenase (NNT) was investigated regarding its physiological role in Caenorhabditis elegans. NNT catalyzes the reduction of NADP(+) by NADH driven by the electrochemical proton gradient, Deltap, and is thus a potentially important source of mitochondrial NADPH. Mitochondrial detoxification of reactive oxygen species (ROS) by glutathione-dependent peroxidases depends on NADPH for regeneration of reduced glutathione… CONTINUE READING

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