A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions.

@article{Rose2009ACS,
  title={A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions.},
  author={Adam J Rose and Thomas Junker Alsted and Thomas E Jensen and J Bjarke Kobber\o and Stine J. Maarbjerg and J\orgen Grue Jensen and Erik A Richter},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 7},
  pages={1547-63}
}
Skeletal muscle protein synthesis rate decreases during contractions but the underlying regulatory mechanisms are poorly understood. It was hypothesized that there would be a coordinated regulation of eukaryotic elongation factor 2 (eEF2) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1) phosphorylation by signalling cascades downstream of rises in intracellular [Ca(2+)] and decreased energy charge via AMP-activated protein kinase (AMPK) in contracting skeletal muscle. When fast… CONTINUE READING