A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis.

@article{Hancock2007ACS,
  title={A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis.},
  author={Anne L. Hancock and Keith W Brown and Kim Moorwood and Hanlim Moon and Claes Holmgren and S. H. Mardikar and Anthony R Dallosso and Elena M Klenova and Dmitri Loukinov and Rolf Ohlsson and Victor V Lobanenkov and Karim Malik},
  journal={Human molecular genetics},
  year={2007},
  volume={16 3},
  pages={
          343-54
        }
}
  • Anne L. Hancock, Keith W Brown, +9 authors Karim Malik
  • Published in Human molecular genetics 2007
  • Biology, Medicine
  • We have shown previously that AWT1 and WT1-AS are functionally imprinted in human kidney. In the adult kidney, expression of both transcripts is restricted to the paternal allele, with the silent maternal allele retaining methylation at the WT1 antisense regulatory region (WT1 ARR). Here, we report characterization of the WT1 ARR differentially methylated region and show that it contains a transcriptional silencer element acting on both the AWT1 and WT1-AS promoters. DNA methylation of the… CONTINUE READING

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