A CRISPR-CAS System Mediates Bacterial Innate Immune Evasion and Virulence

@article{Sampson2013ACS,
  title={A CRISPR-CAS System Mediates Bacterial Innate Immune Evasion and Virulence},
  author={T. Sampson and Sunil D Saroj and Anna C. Llewellyn and Y. Tzeng and D. S. Weiss},
  journal={Nature},
  year={2013},
  volume={497},
  pages={254 - 257}
}
CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) systems are a bacterial defence against invading foreign nucleic acids derived from bacteriophages or exogenous plasmids. These systems use an array of small CRISPR RNAs (crRNAs) consisting of repetitive sequences flanking unique spacers to recognize their targets, and conserved Cas proteins to mediate target degradation. Recent studies have suggested that these systems may have broader functions in bacterial… Expand
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