A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death.

Abstract

West Nile virus (WNV) causes an acute neurological infection attended by massive neuronal cell death. However, the mechanism(s) behind the virus-induced cell death is poorly understood. Using a library containing 77,406 sgRNAs targeting 20,121 genes, we performed a genome-wide screen followed by a second screen with a sub-library. Among the genes identified… (More)
DOI: 10.1016/j.celrep.2015.06.049

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@article{Ma2015ACS, title={A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death.}, author={Hongming Ma and Ying Dang and Yonggan Wu and Gengxiang Jia and Edgar Anaya and Junli Zhang and Sojan Abraham and Jang-gi Choi and Guojun Shi and Ling Qi and N. Manjunath and Haoquan Wu}, journal={Cell reports}, year={2015}, volume={12 4}, pages={673-83} }