A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction.

  title={A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction.},
  author={Salih Eresh and Jens Riese and David B. Jackson and Dirk Bohmann and Mariann Bienz},
  journal={The EMBO journal},
  volume={16 8},
Decapentaplegic (Dpp) is an extracellular signal of the transforming growth factor-beta family with multiple functions during Drosophila development. For example, it plays a key role in the embryo during endoderm induction. During this process, Dpp stimulates transcription of the homeotic genes Ultrabithorax in the visceral mesoderm and labial in the subjacent endoderm. Here, we show that a cAMP response element (CRE) from an Ultrabithorax enhancer mediates Dpp-responsive transcription in the… CONTINUE READING


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