A COMPARISON OF PHENOXYPROPAZINE AND AMYTRYPTILINE IN DEPRESSION.

@article{Rose1963ACO,
  title={A COMPARISON OF PHENOXYPROPAZINE AND AMYTRYPTILINE IN DEPRESSION.},
  author={John T. Rose and M R Leahy and Robert J. Plowman},
  journal={The American journal of psychiatry},
  year={1963},
  volume={120},
  pages={
          393-5
        }
}
Phenoxypropazine is compared with amitryptiline in the treatment of 78 hospitalised patients suffering from primary depressive disorders. Most patients on either drug responded well, there being no significant difference in outcome between the 2 drug groups. Endogenous and reactive depressions showed no difference in response to phenoxypropazine. Side effects were few and did not interfere with treatment. It is considered that phenoxypropazine is a useful antidepressant of equal effectiveness… 
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Part 2. Improvement criteria in drug trials with neurotic patients
TLDR
The principles of the construction of distress scales and the method of testing reliability and validity of scales which purport to measure changes are discussed and the results are compared with studies designed to evaluate the effectiveness of various improvement criteria.