A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE

@article{Biolo1991ACO,
  title={A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE},
  author={Roberta Biolo and Giulio Jori and James C. Kennedy and Pierre Nadeau and Roy H. Pottier and Elena Reddi and Glenn E. Weagle},
  journal={Photochemistry and Photobiology},
  year={1991},
  volume={53}
}
Abstract— The pharmacokinetics of Zn phthalocyanine (ZnPc) encapsulated in dipalmitoyl‐phosphatidyl‐choline (DPPC) liposomes, injected intravenously in Skh:HR‐1 nude mice, was monitored by two in vitro techniques and one in vivo technique, all based on fluorescence spectroscopy. The in vitro methods involve either fluorescence measurements on thin tissue sections or on extracts from these tissues. The in vivo method involves the fluorescence measurement at the skin surface. Both in vitro… 
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Studies on pharmacokinetics of sulfonated aluminum phthalocyanine in a transplantable mouse tumor by in vivo fluorescence.
ON THE SOURCE OF THE OSCILLATIONS OBSERVED DURING in vivo ZINC PHTHALOCYANINE FLUORESCENCE PHARMACOKINETIC MEASUREMENTS IN MICE
TLDR
Surface‐detected fluorescence spectroscopy can be used to monitor the pharmacokinetics of uptake and clearance of red‐absorbing fluorophores such as zinc(II) phthalocyanine (ZnPc) in vivo, but it is important to be aware of the possibility of such artifactual contributions to in vivo fluorescence pharmacokinetic measurements.
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Absorption spectroscopic analysis of the pharmacokinetics of octa-alpha-butyloxy-zinc phthalocyanine in Lewis lung carcinoma-bearing mice
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The rates extracted from the pharmacokinetic model elucidate the mechanisms of drug uptake and retention in the cheek pouch and brain tumor models and should lead to better drug dosimetry for photochemotherapy and allow quick characterization of the Pharmacokinetics of new photosensitizers in tissue.
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References

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TLDR
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TLDR
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