A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE

@article{Biolo1991ACO,
  title={A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE},
  author={Roberta Biolo and Giulio Jori and James C. Kennedy and Pierre Nadeau and Roy H. Pottier and Elena Reddi and Glenn E. Weagle},
  journal={Photochemistry and Photobiology},
  year={1991},
  volume={53}
}
Abstract— The pharmacokinetics of Zn phthalocyanine (ZnPc) encapsulated in dipalmitoyl‐phosphatidyl‐choline (DPPC) liposomes, injected intravenously in Skh:HR‐1 nude mice, was monitored by two in vitro techniques and one in vivo technique, all based on fluorescence spectroscopy. The in vitro methods involve either fluorescence measurements on thin tissue sections or on extracts from these tissues. The in vivo method involves the fluorescence measurement at the skin surface. Both in vitro… 
ON THE SOURCE OF THE OSCILLATIONS OBSERVED DURING in vivo ZINC PHTHALOCYANINE FLUORESCENCE PHARMACOKINETIC MEASUREMENTS IN MICE
TLDR
Surface‐detected fluorescence spectroscopy can be used to monitor the pharmacokinetics of uptake and clearance of red‐absorbing fluorophores such as zinc(II) phthalocyanine (ZnPc) in vivo, but it is important to be aware of the possibility of such artifactual contributions to in vivo fluorescence pharmacokinetic measurements.
Determination of the in vivo pharmacokinetics of palladium-bacteriopheophorbide (WST09) in EMT6 tumour-bearing Balb/c mice using graphite furnace atomic absorption spectroscopy.
TLDR
The results of this study indicate that vascular targeting resulting from WST09 in the circulation, as opposed to selective W ST09 accumulation in tumour tissues, may be responsible for PDT effects in tumours that have been observed in other WST 09 studies.
Absorption spectroscopic analysis of the pharmacokinetics of octa-alpha-butyloxy-zinc phthalocyanine in Lewis lung carcinoma-bearing mice
The phthalocyanines form a continuously growing family of potential photosensitizers. Their chemical and photophysical properties, and therefore their photodynamic activities, are influenced by the
Pharmacokinetics of Photogem using fluorescence monitoring in Wistar rats.
harmaco kinetics of a Fluorescent Drug Using Laser-induced Fluorescence 1
TLDR
The rates extracted from the pharmacokinetic model elucidate the mechanisms of drug uptake and retention in the cheek pouch and brain tumor models and should lead to better drug dosimetry for photochemotherapy and allow quick characterization of the Pharmacokinetics of new photosensitizers in tissue.
l*harmaco kinetics of a Fluorescent Drug Using Laser-induced Fluorescence1
TLDR
The rates extracted from the pharmacokinetic model elucidate the mechanisms of drug uptake and retention in the cheek pouch and brain tumor models and should lead to better drug dosimetry for photochemotherapy and allow quick characterization of the Pharmacokinetics of new photosensitizers in tissue.
A Non-Invasive Technique for in Vivo Pharmacokinetic Measurements Using Optical Fiber Spectrofluorimetry
TLDR
The uptake and subsequent elimination of an exogenous drug from tissues and organs is important pharmalogical data which should be evaluated for any potential drug by the use of in vitro pharmacokinetic studies.
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