# A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE

@article{Biolo1991ACO,
title={A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE},
author={Roberta Biolo and Giulio Jori and James C. Kennedy and Pierre Nadeau and Roy H. Pottier and Elena Reddi and Glenn E. Weagle},
journal={Photochemistry and Photobiology},
year={1991},
volume={53}
}
• Published 1 January 1991
• Biology, Chemistry
• Photochemistry and Photobiology
Abstract— The pharmacokinetics of Zn phthalocyanine (ZnPc) encapsulated in dipalmitoyl‐phosphatidyl‐choline (DPPC) liposomes, injected intravenously in Skh:HR‐1 nude mice, was monitored by two in vitro techniques and one in vivo technique, all based on fluorescence spectroscopy. The in vitro methods involve either fluorescence measurements on thin tissue sections or on extracts from these tissues. The in vivo method involves the fluorescence measurement at the skin surface. Both in vitro…
ON THE SOURCE OF THE OSCILLATIONS OBSERVED DURING in vivo ZINC PHTHALOCYANINE FLUORESCENCE PHARMACOKINETIC MEASUREMENTS IN MICE
• Biology, Chemistry
Photochemistry and photobiology
• 1995
Surface‐detected fluorescence spectroscopy can be used to monitor the pharmacokinetics of uptake and clearance of red‐absorbing fluorophores such as zinc(II) phthalocyanine (ZnPc) in vivo, but it is important to be aware of the possibility of such artifactual contributions to in vivo fluorescence pharmacokinetic measurements.
Determination of the in vivo pharmacokinetics of palladium-bacteriopheophorbide (WST09) in EMT6 tumour-bearing Balb/c mice using graphite furnace atomic absorption spectroscopy.
• Biology
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
• 2004
The results of this study indicate that vascular targeting resulting from WST09 in the circulation, as opposed to selective W ST09 accumulation in tumour tissues, may be responsible for PDT effects in tumours that have been observed in other WST 09 studies.
Absorption spectroscopic analysis of the pharmacokinetics of octa-alpha-butyloxy-zinc phthalocyanine in Lewis lung carcinoma-bearing mice
• Chemistry
Other Conferences
• 1995
The phthalocyanines form a continuously growing family of potential photosensitizers. Their chemical and photophysical properties, and therefore their photodynamic activities, are influenced by the
Pharmacokinetics of Photogem using fluorescence monitoring in Wistar rats.
• Biology, Chemistry
Journal of photochemistry and photobiology. B, Biology
• 2004
harmaco kinetics of a Fluorescent Drug Using Laser-induced Fluorescence 1
• Biology, Chemistry
• 2006
The rates extracted from the pharmacokinetic model elucidate the mechanisms of drug uptake and retention in the cheek pouch and brain tumor models and should lead to better drug dosimetry for photochemotherapy and allow quick characterization of the Pharmacokinetics of new photosensitizers in tissue.
l*harmaco kinetics of a Fluorescent Drug Using Laser-induced Fluorescence1
• Chemistry, Biology
• 2006
The rates extracted from the pharmacokinetic model elucidate the mechanisms of drug uptake and retention in the cheek pouch and brain tumor models and should lead to better drug dosimetry for photochemotherapy and allow quick characterization of the Pharmacokinetics of new photosensitizers in tissue.
A Non-Invasive Technique for in Vivo Pharmacokinetic Measurements Using Optical Fiber Spectrofluorimetry
The uptake and subsequent elimination of an exogenous drug from tissues and organs is important pharmalogical data which should be evaluated for any potential drug by the use of in vitro pharmacokinetic studies.

## References

SHOWING 1-10 OF 28 REFERENCES
Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency.
• Biology, Medicine
British Journal of Cancer
• 1990
It is found that Zn-Pc doses as low as 0.07-0.35 mg kg-1 are sufficient for inducing an efficient tumour response that is linearly dependent on the injected dose, and PDT gives satisfactory results even if performed at relatively long time intervals after administration.
Synthesis, tissue distribution and tumor uptake of 99mTc- and 67Ga-tetrasulfophthalocyanine.
• Chemistry, Biology
The International journal of applied radiation and isotopes
• 1985
Picosecond time-resolved fluorescence spectroscopy of hematoporphyrin derivative
• Physics, Chemistry
• 1984
The picosecond time-resolved fluorescence decays I(t) and spectra I(\lambda, t) for hematoporphyrin derivative (HPD) in a phosphate buffer saline aqueous solution at different concentrations ( 8.4
In Vivo Fluorescence Excitation Spectra of Hematoporphyrin-Derivative (HpD)
• Chemistry, Physics
• 1984
The experiments show that these spectra are different from the fluorescence excitation spectra of HpD solved in saline, which can be explained from the presence of blood in the tumor tissue.
Haematoporphyrin-derivative fluorescence in vitro and in an animal tumour.
• Biology, Physics
• 1983
The experiments show that, firstly, an argon laser can be used as an effective excitation source and, secondly, that the in vivo fluorescence spectrum is different from that in vitro.
The nature of the chromophore responsible for naturally occurring fluorescence in mouse skin.
• Biology, Chemistry
Journal of photochemistry and photobiology. B, Biology
• 1988
Laser-Induced Fluorescence Studies of Hematoporphyrin Derivative (HPD) in Normal and Tumor Tissue of Rat
• Biology, Chemistry
• 1984
Fluorescence studies of hematoporphyrin derivative in normal and tumor tissue of rat were performed with nitrogen laser excitation and optical multi-channel detection and should have implications for practical human HPD endoscopy.
NON‐INVASIVE TECHNIQUE FOR OBTAINING FLUORESCENCE EXCITATION AND EMISSION SPECTRA IN VIVO
• Biology, Chemistry
Photochemistry and photobiology
• 1986
Using this system, it is found possible to obtain good emission and excitation spectra of the material responsible for the weak red fluorescence that characterizes normal mouse skin, and to follow the biosynthesis and subsequent clearance of protoporphyrin IX in the skin of non‐anesthetized mice that had been given various doses of the porphyrIn precursor 5‐aminolevulinic acid.