A CK2-Dependent Mechanism for Degradation of the PML Tumor Suppressor

Abstract

The PML tumor suppressor controls key pathways for growth suppression, induction of apoptosis, and cellular senescence. PML loss occurs frequently in human tumors through unknown posttranslational mechanisms. Casein kinase 2 (CK2) is oncogenic and frequently upregulated in human tumors. Here we show that CK2 regulates PML protein levels by promoting its… (More)
DOI: 10.1016/j.cell.2006.05.041

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