A CHOP-regulated microRNA controls rhodopsin expression

  title={A CHOP-regulated microRNA controls rhodopsin expression},
  author={Shannon L Behrman and Diego Acosta-Alvear and Peter J. Walter},
  booktitle={The Journal of cell biology},
Using genome-wide microribonucleic acid (microRNA [miRNA]) expression profiling, bioinformatics, and biochemical analyses, we identified miR-708, an endoplasmic reticulum (ER) stress-inducible miRNA whose expression is regulated by the transcription factor CCAAT enhancer-binding protein homologous protein (CHOP) in vertebrates. miR-708 is encoded within an intron of the CHOP-regulated gene Odz4, a member of the highly conserved teneurin family of developmental regulators. Odz4 and mir-708… CONTINUE READING


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