A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.

  title={A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.},
  author={Diane D. Mao and Amit D. Gujar and Tatenda Mahlokozera and Ishita Chen and Yanchun Pan and Jingqin Luo and Taylor M. Brost and E. Aubrey Thompson and Alice L. Turski and Eric C. Leuthardt and Gavin P Dunn and Michael Chicoine and Keith M. Rich and Joshua L. Dowling and Gregory Joseph Zipfel and Ralph Dacey and Samuel Achilefu and David Dinh Tran and Hiroko Yano and Albert H. Kim},
  journal={Cell reports},
  volume={11 11},
Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase CDC20-anaphase-promoting complex (CDC20-APC) drives invasiveness and self-renewal in patient tumor… CONTINUE READING
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