A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity.

Abstract

The expedient removal of dying, damaged or altered cells by phagocytosis is essential for homeostasis. However, cancer cells can evade such phagocytic elimination by cell surfaceupregulation of phagocyte-inhibitory signals, such as CD47. CD47 is a prominent ‘don’t eat me’ signal that binds to signalregulatory protein alpha (SIRPa/SIRPA) expressed on… (More)
DOI: 10.1111/bjh.12617

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@article{Wiersma2014ACT, title={A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity.}, author={Valerie R. Wiersma and Yuan He and Douwe F. Samplonius and Robert J. van Ginkel and Jurjen Gerssen and Paul Eggleton and Jin Zhou and Edwin Bremer and Wijnand Helfrich}, journal={British journal of haematology}, year={2014}, volume={164 2}, pages={304-7} }