A CD45 polymorphism associated with abnormal splicing is absent in African populations


The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Abnormal CD45 splicing has been recognized in humans, caused by a C77G transversion in the gene encoding CD45 (PTPRC). Recently the C77G polymorphism has been… (More)
DOI: 10.1007/s00251-001-0410-z


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