A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes

@inproceedings{Horenstein2013ACE,
  title={A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes},
  author={A L Horenstein and Antonella Chillemi and Gianluca Zaccarello and Santina Bruzzone and Valeria Quarona and Andrea Zito and Sara Serra and Fabio Malavasi},
  booktitle={Oncoimmunology},
  year={2013}
}
The tumor microenvironment is characterized by of high levels of extracellular nucleotides that are metabolized through the dynamic and sequential action of cell surface enzymes (ectoenzymes). These ectoenzymes operate according to their spatial arrangement, as part of (1) continuous (molecules on the same cell) or (2) discontinuous (molecules on different cells) pathways, the latter being facilitated by restricted cellular microenvironment. The outcome of this catabolic activity is an increase… CONTINUE READING
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