A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.

@article{Moore2002ACS,
  title={A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.},
  author={Kathryn J. Moore and Joseph B. El Khoury and Lea A. Medeiros and Kinya Terada and Changiz Geula and Andrew D Luster and Mason Wright Freeman},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 49},
  pages={47373-9}
}
beta-Amyloid accumulation is associated with pathologic changes in the brain in Alzheimer's disease and has recently been identified in plaques of another chronic inflammatory disorder, atherosclerosis. The class B scavenger receptor, CD36, mediates binding of fibrillar beta-amyloid to cells of the monocyte/macrophage lineage, including brain macrophages (microglia). In this study, we demonstrate that in microglia and other tissue macrophages, beta-amyloid initiates a CD36-dependent signaling… CONTINUE READING

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