A CD30-positive T cell line established from an aggressive anaplastic large cell lymphoma, originally diagnosed as Hodgkin's disease.

@article{Mistro1994ACT,
  title={A CD30-positive T cell line established from an aggressive anaplastic large cell lymphoma, originally diagnosed as Hodgkin's disease.},
  author={Annarosa Del Mistro and Anna Leszl and Roberta Bertorelle and Maria Luisa Calabr{\'o} and Marina Panozzo and Chiara Menin and E. D'andrea and Luigi Chieco-Bianchi},
  journal={Leukemia},
  year={1994},
  volume={8 7},
  pages={
          1214-9
        }
}
Ten months following the diagnosis of Hodgkin's disease (HD), a 46-year-old woman presented cutaneous and leukemic involvement by CD30+ anaplastic large cells, from which a continuously growing, exogenous growth factor-independent T cell line was established. The cultured cells are phenotypically and genotypically T cell in type, negative for EBV, HTLV-I and HTLV-II viral sequences, and release soluble CD30 into the supernatant. Karyotype analysis disclosed several chromosomal abnormalities… CONTINUE READING

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