A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

@article{Kamei1996ACI,
  title={A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors},
  author={Yasutomi Kamei and Lan Xu and Thorsten Heinzel and Joseph Torchia and Riki Kurokawa and Bernd R Gloss and Sheng-cai Lin and Richard A. Heyman and David W. Rose and Christopher K. Glass and Michael G. Rosenfeld},
  journal={Cell},
  year={1996},
  volume={85},
  pages={403-414}
}
Nuclear receptors regulate gene expression by direct activation of target genes and inhibition of AP-1. Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in cells. Utilizing distinct domains, CBP directly interacts with the ligand-binding domain of multiple nuclear receptors and with the p160 nuclear receptor coactivators… CONTINUE READING
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