A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors

@article{McGaraughty2009ACR,
  title={A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors},
  author={S. McGaraughty and K. Chu and M. J. Dart and B. B. Yao and M. D. Meyer},
  journal={Neuroscience},
  year={2009},
  volume={158},
  pages={1652-1661}
}
  • S. McGaraughty, K. Chu, +2 authors M.D. Meyer
  • Published 2009
  • Medicine, Biology
  • Neuroscience
  • We investigated the systemic and site-specific actions of a selective CB(2) receptor agonist, A-836339 on mechanically evoked (10 g von Frey hair) and spontaneous firing of spinal wide dynamic range (WDR) neurons in neuropathic (L5 and L6 ligations) and sham rats. Systemic administration of A-836339 (0.3-3 micromol/kg, i.v.) reduced both evoked and spontaneous WDR neuronal activity in neuropathic, but not sham rats. The effects in neuropathic rats were blocked by pre-administration of a CB(2… CONTINUE READING
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