A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma

@article{Mandruzzato1997ACM,
  title={A CASP-8 Mutation Recognized by Cytolytic T  Lymphocytes on a Human Head and Neck Carcinoma },
  author={Susanna Mandruzzato and Francis Brasseur and Guy Andry and Thierry Boon and Pierre van der Bruggen},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={785 - 793}
}
Of the antigens recognized on human tumors by autologous cytolytic T lymphocytes, all those defined thus far have been identified on melanoma or renal cell carcinoma. We report here the identification of an antigen recognized by autologous cytolytic T lymphocytes on a human squamous cell carcinoma of the oral cavity. The antigen is encoded by a mutated form of the CASP-8 gene. This gene, also named FLICE or MACH, codes for protease caspase-8, which is required for induction of apoptosis through… CONTINUE READING

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