A CANDLE for a deeper in vivo insight

  title={A CANDLE for a deeper in vivo insight},
  author={Pierrick Coup{\'e} and Martin Munz and Jos{\'e} V. Manj{\'o}n and Edward S. Ruthazer and D. Louis Collins},
  journal={Medical image analysis},
  volume={16 4},
A new Collaborative Approach for eNhanced Denoising under Low-light Excitation (CANDLE) is introduced for the processing of 3D laser scanning multiphoton microscopy images. CANDLE is designed to be robust for low signal-to-noise ratio (SNR) conditions typically encountered when imaging deep in scattering biological specimens. Based on an optimized non-local means filter involving the comparison of filtered patches, CANDLE locally adapts the amount of smoothing in order to deal with the noise… CONTINUE READING
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