A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage.

@article{Moggs2000ACC,
  title={A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage.},
  author={Jonathan G. Moggs and Paola Grandi and Jean-Pierre Quivy and Zophon{\'i}as Oddur J{\'o}nsson and Ulrich Huebscher and Peter B. Becker and Genevi{\`e}ve Almouzni},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 4},
  pages={
          1206-18
        }
}
Sensing DNA damage is crucial for the maintenance of genomic integrity and cell cycle progression. The participation of chromatin in these events is becoming of increasing interest. We show that the presence of single-strand breaks and gaps, formed either directly or during DNA damage processing, can trigger the propagation of nucleosomal arrays. This nucleosome assembly pathway involves the histone chaperone chromatin assembly factor 1 (CAF-1). The largest subunit (p150) of this factor… CONTINUE READING
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