A C. elegans mutant that lives twice as long as wild type

@article{Kenyon1993ACE,
  title={A C. elegans mutant that lives twice as long as wild type},
  author={Cynthia Kenyon and Jean Chang and Erin Gensch and Adam D Rudner and Ramon K. Tabtiang},
  journal={Nature},
  year={1993},
  volume={366},
  pages={461-464}
}
WE have found that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type. This lifespan extension, the largest yet reported in any organism1, requires the activity of a second gene, daf-16. Both genes also regulate formation of the dauer larva, a developmentally arrested larval form that is induced by crowding and starvation and is very long-lived2–4. Our findings raise the possibility that the longevity… Expand
Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes
TLDR
Analysis of the phenotypes of these mutants suggests the existence of a general physiological clock in the worm, and the daf-2(e1370) clk-1(e2519) worms, which carry life-span-extending mutations from two different pathways, live nearly five times as long as wild-type worms. Expand
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.
TLDR
The strengths of the Daf-c, Age, and Itt phenotypes largely correlated with each other but not with the strength of class 2-specific defects, which suggests that the DAF-2 receptor is bifunctional. Expand
Molecular genetics of life span in C. elegans: how much does it teach us?
TLDR
Three genes in the nematode worm Caenorhabditis elegans, age-1, daf-2 and clk-2, have now been cloned and encodes a protein of unknown biochemical function similar to the yeast metabolic regulator Cat5p/Coq7p. Expand
Modulation of kinase activities in dauers and in long-lived mutants of Caenorhabditis elegans.
TLDR
Elevated levels of PKA and PTK were present in dauer larvae, developmentally arrested juveniles specialized for long-term survival, relative to L3 larvae, the alternative developmental stage, and age-1 and daf-2 mutant worms may express distinct elements of a dauer-specific survival program during adult life. Expand
Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity.
TLDR
All the known classes of dauer formation (Daf) mutant that affect longevity were found, including six new alleles of daf-2, and a unique temperature-sensitive, dauer-constitutive allele of age-1. Expand
Genetic control of longevity in C. elegans
TLDR
The nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity and those related to the Ins/IGF signaling pathway are among the best studied and will be focused on in this review. Expand
Defining wild-type life span in Caenorhabditis elegans.
  • D. Gems, D. Riddle
  • Biology, Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2000
TLDR
It is inferred that the longest-lived N2 variant best resembles the original N2 isolate, which is the N2 male stock currently distributed by the Caenorhabditis Genetics Center. Expand
Stress response and aging in Caenorhabditis elegans.
  • G. Lithgow
  • Biology, Medicine
  • Results and problems in cell differentiation
  • 2000
TLDR
Mutants of C. elegans that exhibit extraordinarily long life-spans are proving a rich source of information on the molecular determinates of aging rate, including resistance to a variety of extrinsic environmental stresses. Expand
C. elegans as a premier longevity and aging model
and aging model Aging studies in mammals are challenging owing to relatively long life spans and a limited set of genetic tools that are capable of assessing the genome-wide changes associated withExpand
Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease
TLDR
It is suggested that the role of the Age genes in both longevity and stress resistance indicates that a major evolutionary determinant of longevity is the ability to respond to stress. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans.
  • T. Johnson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1987
The aging process has been dissected by analysis of genetic variants of the nematode Caenorhabditis elegans. Long-lived recombinant inbred lines were generated; some of these lines have mean andExpand
Non-ageing developmental variant of Caenorhabditis elegans
TLDR
Larval forms of the free-living soil nema-tode, Caenorhabditis elegans, possess the ability to enter a semi-dormant, quiescent state referred to as the dauer larval stage (German, “enduring” larva), which enables the species to retard its ageing rate and extend its life span. Expand
Critical periods in the development of the Caenorhabditis elegans dauer larva.
TLDR
Temperature-sensitive mutants representing six different genes have been subjected to temperature-shift and -pulse experiments in order to define the times of temperature sensitivity (TSPs), and the exceptional mutant, daf-14, has its TSP within the first larval stage. Expand
Production of sperm reduces nematode lifespan
TLDR
It is reported here that in the soil nematode, Caenorhabditis elegans, sex significantly decreases male lifespan without reducing hermaphrodite lifespan, suggesting that spermatogenesis, rather than oogenesis or the physical act of mating, is a major factor reducing lifespan in C. elegans. Expand
The Nematode Caenorhabditis elegans
TLDR
This "Book of the Worm" serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists. Expand
Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span
  • M. Klass
  • Medicine, Biology
  • Mechanisms of Ageing and Development
  • 1977
TLDR
The present study identifies some of the major biological and environmental factors influencing life span as a prelude to more detailed genetic and biochemical analyses in Caenorhabditis elegans. Expand
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
TLDR
Results suggest that daf-11 is directly involved in chemosensory transduction essential for dauer formation, while the other Daf-c genes play roles downstream of the chemosENSory step. Expand
Genetic analysis of life-span in Caenorhabditis elegans.
  • T. Johnson, W. Wood
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1982
TLDR
It is concluded that life-span variation in C. elegans has a substantial genetic component and that this organism offers promising opportunities for selective breeding of longer-lived strains and genetic analysis of senescence. Expand
Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans
TLDR
The activities of cell signals and pal-1 appear to influence V cell fates by determining the state of a developmental switch that involves two homeotic genes, lin-22 and mab-5. Expand
Sex determination in the nematode C. elegans: analysis of tra-3 suppressors and characterization of fem genes.
TLDR
All three fem genes are essential for male development and appear to have a dual role in promoting spermatogenesis and repressing tra-1 activity; the maternal contribution of fem gene products may be inactivated in XX animals by a posttranscriptional mechanism. Expand
...
1
2
...