A C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration.

@article{Pickett2007ACE,
  title={A C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration.},
  author={Christopher L Pickett and Kevin T. Breen and Donald E. Ayer},
  journal={Developmental biology},
  year={2007},
  volume={310 2},
  pages={226-39}
}
Myc and Mondo proteins are key regulators of cell growth, proliferation, and energy metabolism, yet often overlooked is their vital role in cell migration. Complex networks of protein-protein and protein-DNA interactions control the transcriptional activity of Myc and MondoA confounding their functional analysis in higher eukaryotes. Here we report the identification of the transcriptional activation arm of a simplified Myc-like network in Caenorhabditis elegans. This network comprises an Mlx… CONTINUE READING
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