A C-terminus Mitochondrial-localization Region and BH3 Domain of Puma are Required for Apoptotic Function

@inproceedings{Merwin2013ACM,
  title={A C-terminus Mitochondrial-localization Region and BH3 Domain of Puma are Required for Apoptotic Function},
  author={Liz A. Merwin},
  year={2013}
}
Apoptosis is known to contribute to the loss of neurological function in brain injury and several neurodegenerative diseases. The Bcl-2 family of proteins consist of pro-apoptotic and anti-apoptotic members that interact physically and functionally to regulate apoptosis in a cell type and stimulus specific manner. We have previously demonstrated that the Bcl-2 family member Puma plays a key role in triggering neuronal apoptosis under diverse stress conditions. However, the mechanism by which… CONTINUE READING

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