A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.

@article{Hall1998ACM,
  title={A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.},
  author={R A Hall and Lynda S. Ostedgaard and Richard T Premont and Jeremy T. Blitzer and N Rahman and M J Welsh and R J Lefkowitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 15},
  pages={8496-501}
}
  • R A Hall, Lynda S. Ostedgaard, +4 authors R J Lefkowitz
  • Published 1998 in
    Proceedings of the National Academy of Sciences…
The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na+/H+ exchange. NHERF contains two PDZ domains, the first of which is required for its interaction with the beta2 receptor. Mutagenesis studies of the beta2 receptor tail revealed that the optimal C-terminal motif for binding to the first PDZ domain of NHERF is D-S/T-x-L, a motif distinct from those recognized by other PDZ domains. The first PDZ domain… CONTINUE READING
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