A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels.

@article{Rosmond2002ACP,
  title={A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels.},
  author={Roland Rosmond and Claude Bouchard and Per Bj{\"o}rntorp},
  journal={Journal of internal medicine},
  year={2002},
  volume={251 3},
  pages={252-7}
}
OBJECTIVES The objective of the current study was to examine the potential impact of a C right arrow G substitution at position -1291 of the alpha2A-adrenergic receptor gene (ADRA2A) promoter on obesity and estimates of insulin, glucose, and lipid metabolism as well as circulating hormones, including salivary cortisol in 284 unrelated Swedish men born in 1944. MAIN OUTCOME MEASURES The subjects were genotyped by using PCR amplification of the promoter region of the ADRA2A gene followed by… CONTINUE READING

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