A Butyrophilin Family Member Critically Inhibits T Cell Activation

  title={A Butyrophilin Family Member Critically Inhibits T Cell Activation},
  author={Tomohide Yamazaki and Íñigo Goya and Daniel Graf and Suzanne L. Craig and Natalia Mart{\'i}n‐Orozco and Chen Dong},
  journal={The Journal of Immunology},
  pages={5907 - 5914}
The costimulatory molecules in the B7-CD28 families are important in the regulation of T cell activation and tolerance. The butyrophilin family of proteins shares sequence and structure homology with B7 family molecules; however, the function of the butyrophilin family in the immune system has not been defined. In this study, we performed an analysis on multiple butyrophilin molecules and found that butyrophilin-like (BTNL)1 molecule functions to dampen T cell activation. BTNL1 mRNA was broadly… 

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