A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood

@inproceedings{Cartwright2016ABI,
  title={A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood},
  author={Mark J. Cartwright and Martin Rottman and Nathan I Shapiro and Benjamin T Seiler and Patrick Lombardo and Nazita Gamini and Julie Tomolonis and Alexander L. Watters and Anna Waterhouse and Dan B Leslie and Dana E. Bolgen and Amanda Graveline and Joo Hyoung Kang and Tohid F Didar and Nikolaos Dimitrakakis and D. Kelly Cartwright and Michael Super and Donald E. Ingber},
  booktitle={EBioMedicine},
  year={2016}
}
BACKGROUND Blood cultures, and molecular diagnostic tests that directly detect pathogen DNA in blood, fail to detect bloodstream infections in most infected patients. Thus, there is a need for a rapid test that can diagnose the presence of infection to triage patients, guide therapy, and decrease the incidence of sepsis. METHODS An Enzyme-Linked Lectin-Sorbent Assay (ELLecSA) that uses magnetic microbeads coated with an engineered version of the human opsonin, Mannose Binding Lectin… CONTINUE READING

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