A Brief History of Carbon Monoxide and Its Therapeutic Origins.

  title={A Brief History of Carbon Monoxide and Its Therapeutic Origins.},
  author={Christopher P. Hopper and Paige N. Zambrana and Ulrich Goebel and Jakob Wollborn},
  journal={Nitric oxide : biology and chemistry},

Flavonol-Based Carbon Monoxide Delivery Molecule with Endoplasmic Reticulum, Mitochondria, And Lysosome Localization.

The first example of a metal free CO delivery molecule that can be tracked via confocal microscopy at low micromolar concentrations in cells prior to CO release is reported, where the NEt2-appended extended flavonol localizes to the endoplasmic reticulum, mitochondria, and lysosomes.

The brain heme oxygenase/biliverdin reductase system as a target in drug research and development

  • C. Mancuso
  • Biology
    Expert opinion on therapeutic targets
  • 2022
The paper analyzes the main classes of drugs acting on the nervous system, with HO as second-level target, and their neuroprotective potential, and the difficulties that exist for the development of drugsacting on HO/BVR are examined.

Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease

The current knowledge of NO, CO, and H2S implicated in pregnancy, including in physiological and pathophysiological processes, is described, highlighting their key roles in hypertension and kidney disease.

Gases in Sepsis: Novel Mediators and Therapeutic Targets

The state-of-the-art knowledge on the pathophysiology of sepsis; the metabolism and physiological function of NO, CO and H2S; the crosstalk among these gaseous mediators; and their crucial effects on the development and progression of Sepsis are summarized.

Correction: Improving on estimates of the potential relative harm to health from using modern ENDS (vaping) compared to tobacco smoking

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any



Friend or foe? Carbon monoxide and the mitochondria

The body of evidence supporting a physiological role for CO is immense and continues to move forward as CO is being evaluated in ongoing clinical trials ( www.clinicaltrials. gov, Identifier: NCT 01727167).

Antibacterial effects of carbon monoxide.

Data is reviewed suggesting that CO-RMs are more effective inhibitors of respiration than is CO gas, perhaps due to the ability of CO- RMs to deliver CO selectively to intracellular targets.

Biological signaling by carbon monoxide and carbon monoxide-releasing molecules.

How the binding of CO with key ferrous hemoproteins serves as a posttranslational modification that regulates important processes as diverse as aerobic metabolism, oxidative stress, and mitochondrial bioenergetics is discussed.

Strategies toward Organic Carbon Monoxide Prodrugs.

This Account describes the work in this area as well as the demonstration for these organic CO prodrugs to recapitulate CO's pharmacological effects both in vitro and in vivo and proposes a new concept of "enrichment triggered CO release" by conjugating both components with a mitochondria-targeting moiety to achieve targeted CO delivery with improved biological outcomes.

Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule.

CO at low concentrations, concentrations that are well below those that would otherwise create toxic effects, is proving beneficial in models of acute injury and is proving to be an extraordinary signaling molecule generated by the cell that is vital in the regulation of cellular homeostasis.

Carbon monoxide in intensive care medicine—time to start the therapeutic application?!

The current understanding of carbon monoxide’s biology and its possible organ targets to treating the critically ill patients in tomorrow's ICU are summarized.

Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics?

Heme oxygenase (HO), the rate-limiting step in the degradation of heme to biliverdin, ferrous ion, and carbon monoxide (CO), is an ancestral protective enzyme conserved across phylogenetic domains.