A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake

@article{Holland2019ABA,
  title={A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake},
  author={J. Holland and J. Sorrell and Emily Yates and Kathleen Smith and S. Arbabi and M. Arnold and Marita Rivir and Rachel L. Morano and Jenny Chen and X. Zhang and R. DiMarchi and S. Woods and J. Sanchez-Gurmaches and E. Wohleb and D. P{\'e}rez-Tilve},
  journal={Cell reports},
  year={2019},
  volume={27},
  pages={2399 - 2410.e6}
}
SUMMARY The melanocortin system is a brain circuit that influences energy balance by regulating energy intake and expenditure. In addition, the brain-melanocortin system controls adipose tissue metabolism to optimize fuel mobilization and storage. Specifically, increased brain-melanocortin signaling or negative energy balance promotes lipid mobilization by increasing sympathetic nervous system input to adipose tissue. In contrast, calorie-independent mechanisms favoring energy storage are less… Expand

References

SHOWING 1-10 OF 70 REFERENCES
The central melanocortin system directly controls peripheral lipid metabolism.
Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue.
The central melanocortin system can directly regulate serum insulin levels.
Inhibition of the central melanocortin system decreases brown adipose tissue activity[S]
Neural innervation of white adipose tissue and the control of lipolysis
Lipolysis sensation by white fat afferent nerves triggers brown fat thermogenesis
Regulation of substrate utilization and adiposity by Agrp neurons
Vagus Nerve Stimulation Increases Energy Expenditure: Relation to Brown Adipose Tissue Activity
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