A Boolean Model of the Gene Regulatory Network Underlying Mammalian Cortical Area Development

  title={A Boolean Model of the Gene Regulatory Network Underlying Mammalian Cortical Area Development},
  author={Clare E. Giacomantonio and Geoffrey J. Goodhill},
  booktitle={PLoS Computational Biology},
The cerebral cortex is divided into many functionally distinct areas. The emergence of these areas during neural development is dependent on the expression patterns of several genes. Along the anterior-posterior axis, gradients of Fgf8, Emx2, Pax6, Coup-tfi, and Sp8 play a particularly strong role in specifying areal identity. However, our understanding of the regulatory interactions between these genes that lead to their confinement to particular spatial patterns is currently qualitative and… CONTINUE READING
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