A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

  title={A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells},
  author={B. Bernstein and T. Mikkelsen and X. Xie and M. Kamal and Dana J. Huebert and J. Cuff and B. Fry and A. Meissner and M. Wernig and K. Plath and R. Jaenisch and A. Wagschal and R. Feil and S. Schreiber and E. Lander},
  • B. Bernstein, T. Mikkelsen, +12 authors E. Lander
  • Published 2006
  • Medicine, Biology
  • Cell
  • The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that HCNE-rich regions may contain key regulatory controls involved in development. We explored this by examining histone methylation in mouse embryonic stem (ES) cells across 56 large HCNE-rich loci. We identified a specific modification pattern, termed "bivalent domains," consisting of large regions of… CONTINUE READING

    Figures and Topics from this paper.

    Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells
    • 102
    • Highly Influenced
    • PDF
    Bivalent histone modifications in early embryogenesis.
    • 189
    • PDF


    Publications referenced by this paper.
    Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping.
    • 449
    • PDF
    Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse
    • 1,441
    Histone Code Modifications on Pluripotential Nuclei of Reprogrammed Somatic Cells
    • 213
    • PDF
    Role of transposable elements in heterochromatin and epigenetic control
    • 1,087
    • PDF
    Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
    • 4,012
    • PDF
    The profile of repeat‐associated histone lysine methylation states in the mouse epigenome
    • 609
    Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription.
    • 642
    • PDF
    The epigenetic basis for embryonic stem cell pluripotency.
    • 63
    • PDF
    Global and Hox-specific roles for the MLL1 methyltransferase.
    • 330
    • PDF
    The Polycomb-Group GeneEzh2 Is Required for Early Mouse Development
    • 619
    • PDF