A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

@article{Bernstein2006ABC,
  title={A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells},
  author={B. Bernstein and T. Mikkelsen and X. Xie and M. Kamal and Dana J. Huebert and J. Cuff and B. Fry and A. Meissner and M. Wernig and K. Plath and R. Jaenisch and A. Wagschal and R. Feil and S. Schreiber and E. Lander},
  journal={Cell},
  year={2006},
  volume={125},
  pages={315-326}
}
  • B. Bernstein, T. Mikkelsen, +12 authors E. Lander
  • Published 2006
  • Medicine, Biology
  • Cell
  • The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that HCNE-rich regions may contain key regulatory controls involved in development. We explored this by examining histone methylation in mouse embryonic stem (ES) cells across 56 large HCNE-rich loci. We identified a specific modification pattern, termed "bivalent domains," consisting of large regions of… CONTINUE READING

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