A Birth-Season/DRD4 Gene Interaction Predicts Weight Gain and Obesity in Women with Seasonal Affective Disorder: A Seasonal Thrifty Phenotype Hypothesis

@article{Levitan2006ABG,
  title={A Birth-Season/DRD4 Gene Interaction Predicts Weight Gain and Obesity in Women with Seasonal Affective Disorder: A Seasonal Thrifty Phenotype Hypothesis},
  author={Robert Levitan and Mario Masellis and Raymond W. Lam and Allan S. Kaplan and Caroline A. Davis and Subi Tharmalingam and Bronwyn E Mackenzie and Vincenzo Santo Basile and James L. Kennedy},
  journal={Neuropsychopharmacology},
  year={2006},
  volume={31},
  pages={2498-2503}
}
We have recently described an association between the hypofunctional 7-repeat allele (7R) of the dopamine-4 receptor gene (DRD4), weight gain, and obesity in women with seasonal affective disorder (SAD). In the current study, we examined whether season-of-birth might interact with the 7R allele to influence body weight regulation in SAD. In 182 female probands with SAD, we performed an analysis of covariance predicting maximum lifetime body mass index (BMI) with both the exon-3 variable number… 

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