A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases

@article{Barua2009ABC,
  title={A Bipolar Clamp Mechanism for Activation of Jak-Family Protein Tyrosine Kinases},
  author={Dipak Barua and James R. Faeder and Jason M. Haugh},
  journal={PLoS Computational Biology},
  year={2009},
  volume={5},
  pages={225 - 235}
}
Most cell surface receptors for growth factors and cytokines dimerize in order to mediate signal transduction. For many such receptors, the Janus kinase (Jak) family of non-receptor protein tyrosine kinases are recruited in pairs and juxtaposed by dimerized receptor complexes in order to activate one another by trans-phosphorylation. An alternative mechanism for Jak trans-phosphorylation has been proposed in which the phosphorylated kinase interacts with the Src homology 2 (SH2) domain of SH2-B… CONTINUE READING
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