A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

@article{Reimann2013ABD,
  title={A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents},
  author={Michael W. Reimann and C. Anastassiou and R. Perin and Sean L. Hill and H. Markram and C. Koch},
  journal={Neuron},
  year={2013},
  volume={79},
  pages={375-390}
}
Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but neither the detailed biophysical knowledge nor the required computational power have been available to model these processes. We simulated the LFP in a model of the rodent neocortical column composed of >12,000 reconstructed, multicompartmental… Expand
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