A Biophysical Model for Identifying Splicing Regulatory Elements and Their Interactions

@inproceedings{Wen2013ABM,
  title={A Biophysical Model for Identifying Splicing Regulatory Elements and Their Interactions},
  author={Ji Wen and Zhibin Chen and Xiaodong Cai},
  booktitle={PloS one},
  year={2013}
}
Alternative splicing (AS) of precursor mRNA (pre-mRNA) is a crucial step in the expression of most eukaryotic genes. Splicing factors (SFs) play an important role in AS regulation by binding to the cis-regulatory elements on the pre-mRNA. Although many splicing factors (SFs) and their binding sites have been identified, their combinatorial regulatory effects remain to be elucidated. In this paper, we derive a biophysical model for AS regulation that integrates combinatorial signals of cis… CONTINUE READING
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