A Bioartificial Liver--State of the Art

@article{Strain2002ABL,
  title={A Bioartificial Liver--State of the Art},
  author={Alastair J. Strain and James Neuberger},
  journal={Science},
  year={2002},
  volume={295},
  pages={1005 - 1009}
}
End-stage liver disease is treated by liver transplantation, but donor organ shortages remain a serious problem. This has prompted the design of bioartificial liver devices to “bridge” patients until they either recover or receive a liver transplant. In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries. 
Hepatocyte Culture Technology and its Application to Bioartificial Liver
The liver is mutifunctional vital organ for healthy survival and orthotopic liver transplatation is the only definitive therapy for patients with acute or fulminant hepatic failure (FHF) so far.
Hepatocyte transplantation: State of the art.
TLDR
Progresses regarding hepatocyte culture, cryopreservation systems, hepatocyte immortalization, suitable recipient site for hepatocyte engraftment, cell differentiation and fusion into hepatocytes, current clinical trials, and summarize the bioartificial liver systems motivate expectation concerning hepatocyte transplantation as a consistent therapy for liver disease.
BIO-ARTIFICIAL LIVER
A person suffering from acute liver failure requires liver transplantation. But the availability of donor organ is always a serious problem and is costly. Here bio-artificial liver comes into play
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TLDR
Which hurdles have to be taken before the BAL will become standard equipment in the intensive care unit for patients with acute liver failure or acute deterioration of chronic liver disease are analyzed.
Liver replacement therapy.
The realization of a support device able to effectively replace liver function in patients with hepatic failure has thus far been an elusive goal. The complexity of liver metabolic, synthetic,
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The authors describe the critical issues involved in bioartificial liver development and discuss their experiences in hepatocyte culture optimization within the context of a microchannel, flat-plate bioart artificial liver device with an internal membrane oxygenator.
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The ability of a self-assembling peptide nanofiber (SAPNF) to provide a provisional three-dimensional support to interact with cells to control their function in vivo was tested and extensive cell–cell communication and preservation of hepatocyte architecture was indicated.
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TLDR
An overview of efficacy of various liver support systems that are currently available is given, which has been analyzed for improving the important system component such as cell source and other culture and circulation conditions for the maintenance of the liver-specific functions.
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    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
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TLDR
It is shown that it is possible to use the vast majority of livers not suitable for transplantation on a national basis for human hepatocyte isolation, obtaining a large amount of viable functioning human hepatocytes that might be used for cell transplantation and therapy.
[Hepatic tissue engineering].
  • H. Fiegel, U. Kneser, D. Kluth, U. Rolle
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    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...
  • 2010
TLDR
In cultures of hepatocytes a regulation of cell proliferation and specific function by using three-dimensional matrices and by modifying the surface with isolated molecules of the extracellular matrix has been demonstrated and a beneficial effect of a flow bioreactor system on cell viability and function was observed.
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A hybrid bioartificial liver has been developed on the principle of hemodialysis against a suspension of functioning hepatocytes and was used successfully to treat a patient in hepatic failure due to an inoperable bile duct carcinoma that involved the bifurcation of the common duct.
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