A Big Bang in spliceosome structural biology

@article{Cate2016ABB,
  title={A Big Bang in spliceosome structural biology},
  author={Jamie H. D. Cate},
  journal={Science},
  year={2016},
  volume={351},
  pages={1390 - 1392}
}
  • J. Cate
  • Published 25 March 2016
  • Biology, Medicine
  • Science
3D snapshots reveal dynamics of the spliceosome on the mRNA splicing pathway [Also see Research Article by Agafonov et al.] Look at a protein-coding gene in the genome of any eukaryote—be it animal, plant, fungus, or protist—and you will likely find the coding region fragmented by intervening sequences known as introns. When the gene is transcribed, these introns have to be removed from the pre-messenger RNA (pre-mRNA) before a protein can be made. How these introns are removed has been studied… 
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