A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity

@article{Brubaker2014ABM,
  title={A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity},
  author={Sky W. Brubaker and Anna E. Gauthier and Eric W Mills and Nicholas T Ingolia and Jonathan C. Kagan},
  journal={Cell},
  year={2014},
  volume={156},
  pages={800-811}
}
Bacterial and viral mRNAs are often polycistronic. Akin to alternative splicing, alternative translation of polycistronic messages is a mechanism to generate protein diversity and regulate gene function. Although a few examples exist, the use of polycistronic messages in mammalian cells is not widely appreciated. Here we report an example of alternative translation as a means of regulating innate immune signaling. MAVS, a regulator of antiviral innate immunity, is expressed from a bicistronic… CONTINUE READING