A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis

@article{Kesner2004ABA,
  title={A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis},
  author={Raymond P. Kesner and Inah Lee and Peter F. C. Gilbert},
  journal={Reviews in the Neurosciences},
  year={2004},
  volume={15},
  pages={333 - 352}
}
The purpose of this review is to determine whether specific subregions (dentate gyrus [DG], CA3, and CA1) of the hippocampus provide unique contributions to specific processes associated with intrinsic information processing exemplified by novelty detection, encoding, pattern separation, pattern association, pattern completion, retrieval, short-term memory and intermediate-term memory. Based on anatomical neural network organization, electrophysiology of cellular activity, lesions, early gene… 

Tables from this paper

The role of the CA3 hippocampal subregion in spatial memory: A process oriented behavioral assessment
A process analysis of the CA3 subregion of the hippocampus
  • R. Kesner
  • Biology, Psychology
    Front. Cell. Neurosci.
  • 2013
TLDR
From a behavioral perspective, the CA3a,b subregion of the hippocampus plays an important role in the encoding of new spatial information within short-term memory with a duration of seconds and minutes and supports retrieval of short- term memory information based on a spatial pattern completion process.
A computational theory of hippocampal function, and empirical tests of the theory
The interactions and dissociations of the dorsal hippocampus subregions: how the dentate gyrus, CA3, and CA1 process spatial information.
TLDR
The results of the present study suggest that dCA1, but not dDDG or dCA3, mediates topological memory, and Furthermore, dDG, d CA3, and d CA1 mediate metric memory.
Behavioral functions of the CA3 subregion of the hippocampus.
  • R. Kesner
  • Biology, Psychology
    Learning & memory
  • 2007
TLDR
From a behavioral perspective, the CA3a,b subregion of the hippocampus plays an important role in the encoding of new spatial information within short-term memory with a duration of seconds and minutes and plays a role in sequential processing of information in cooperation with CA1 based on the Schaffer collateral output from CA3,b to CA1.
A behavioral analysis of dentate gyrus function.
  • R. Kesner
  • Psychology, Biology
    Progress in brain research
  • 2007
Pattern separation in the dentate gyrus: A role for the CA3 backprojection
TLDR
A simple CA3 network model is considered, and it is hypothesize that CA3 backprojections might play an important role in hippocampal function, and shows that the DG‐CA3 model with backprojection provides a better fit to empirical data than a model without back projections.
Mnemonic contributions of hippocampal place cells
...
...

References

SHOWING 1-10 OF 113 REFERENCES
A theory of hippocampal function in memory
  • E. Rolls
  • Biology, Psychology
    Hippocampus
  • 1996
TLDR
Key hypotheses are that the CA3 pyramidal cells operate as a single autoassociation network to store new episodic information as it arrives via a number of specialized preprocessing stages from many different association areas of the cerebral cortex, and that the dentate granule cell/mossy fiber system is important particularly during learning to help to produce a new pattern of firing in theCA3 cells for each episode.
Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay.
TLDR
A dynamic interaction among the dorsal hippocampal subregions in processing spatial working memory is suggested, with the time window of a task recognized as an essential controlling factor.
Localization of function within the dorsal hippocampus: the role of the CA3 subregion in paired-associate learning.
TLDR
The data indicate that rats with DG or CA1 lesions learned the tasks as well as controls; however, CA3-lesioned rats were impaired in learning the tasks, suggesting the CA3 subregion of the dorsal hippocampus contains a mechanism to support paired-associate learning.
Differential contributions of dorsal hippocampal subregions to memory acquisition and retrieval in contextual fear‐conditioning
TLDR
It is suggested that all three subregions (i.e., CA3, CA1, and dentate gyrus) of the hippocampus contribute to rapid acquisition of contextual memory in the initial phase of acquisition.
Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade‐off
TLDR
This analysis is focused on the feedforward pathways from the entorhinal cortex to the dentate gyrus (DG) and region CA3 and finds that Hebbian synaptic modification facilitates completion but reduces separation, unless the strengths of synapses from inactive presynaptic units to active postsynaptic units are reduced (LTD).
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
TLDR
Results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall by generating and analyzing a genetically engineered mouse strain in which the N-methyl-d-asparate (NMDA) receptor gene is ablated specifically in the CA3 pyramidal cells of adult mice.
Mapping Brain Networks Engaged by, and Changed by, Learning
TLDR
The results demonstrate that the balance of neuronal activity both within and between limbic structures changes across sequential stages of odor learning in a fashion that is likely to define behavioral output.
Encoding versus retrieval of spatial memory: Double dissociation between the dentate gyrus and the perforant path inputs into CA3 in the dorsal hippocampus
TLDR
The results suggest that the two major afferent inputs of CA3 may contribute differentially to encoding and retrieval of spatial memory.
Hippocampal granule cells are necessary for normal spatial learning but not for spatially-selective pyramidal cell discharge
TLDR
Most of the spatial information exhibited by hippocampal pyramidal cells is likely to be transmitted from the cortex by routes other than the traditional “trisynaptic circuit”, including the direct projections from entorhinal layers II and III to CA3 and CA1, respectively.
...
...