A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis

@article{Kesner2004ABA,
  title={A Behavioral Assessment of Hippocampal Function Based on a Subregional Analysis},
  author={Raymond P. Kesner and Inah Lee and Peter F. C. Gilbert},
  journal={Reviews in the Neurosciences},
  year={2004},
  volume={15},
  pages={333 - 352}
}
The purpose of this review is to determine whether specific subregions (dentate gyrus [DG], CA3, and CA1) of the hippocampus provide unique contributions to specific processes associated with intrinsic information processing exemplified by novelty detection, encoding, pattern separation, pattern association, pattern completion, retrieval, short-term memory and intermediate-term memory. Based on anatomical neural network organization, electrophysiology of cellular activity, lesions, early gene… 
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TLDR
The results of the present study suggest that dCA1, but not dDDG or dCA3, mediates topological memory, and Furthermore, dDG, d CA3, and d CA1 mediate metric memory.
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  • R. Kesner
  • Biology, Psychology
    Learning & memory
  • 2007
TLDR
From a behavioral perspective, the CA3a,b subregion of the hippocampus plays an important role in the encoding of new spatial information within short-term memory with a duration of seconds and minutes and plays a role in sequential processing of information in cooperation with CA1 based on the Schaffer collateral output from CA3,b to CA1.
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Computational Models of Hippocampal Functions
Pattern separation in the dentate gyrus: A role for the CA3 backprojection
TLDR
A simple CA3 network model is considered, and it is hypothesize that CA3 backprojections might play an important role in hippocampal function, and shows that the DG‐CA3 model with backprojection provides a better fit to empirical data than a model without back projections.
Mnemonic contributions of hippocampal place cells
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