A Bayesian population PBPK model for multiroute chloroform exposure

@article{Yang2010ABP,
  title={A Bayesian population PBPK model for multiroute chloroform exposure},
  author={Yuching Yang and Xu Xu and Panos G. Georgopoulos},
  journal={Journal of Exposure Science and Environmental Epidemiology},
  year={2010},
  volume={20},
  pages={326-341}
}
A Bayesian hierarchical model was developed to estimate the parameters in a physiologically based pharmacokinetic (PBPK) model for chloroform using prior information and biomarker data from different exposure pathways. In particular, the model provides a quantitative description of the changes in physiological parameters associated with hot-water bath and showering scenarios. Through Bayesian inference, uncertainties in the PBPK parameters were reduced from the prior distributions. Prediction… 
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