A Bayesian phylogenetic method to estimate unknown sequence ages.

  title={A Bayesian phylogenetic method to estimate unknown sequence ages.},
  author={Beth Shapiro and Simon Y. W. Ho and Alexei J. Drummond and Marc A. Suchard and Oliver G. Pybus and Andrew Rambaut},
  journal={Molecular biology and evolution},
  volume={28 2},
Heterochronous data sets comprise molecular sequences sampled at different points in time. If the temporal range of the sampled sequences is large relative to the rate of mutation, the sampling times can directly calibrate evolutionary rates to calendar time. Here, we extend this calibration process to provide a full probabilistic method that utilizes temporal information in heterochronous data sets to estimate sampling times (leaf-ages) for sequenced for which this information unavailable. Our… CONTINUE READING
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