A Bayesian method for single molecule, fluorescence burst analysis

  title={A Bayesian method for single molecule, fluorescence burst analysis},
  author={Paul R. Barber and Simon M Ameer-Beg and S. Pathmananthan and M. Rowley and Anthony C. C. Coolen},
  booktitle={Biomedical optics express},
There is currently great interest in determining physical parameters, e.g. fluorescence lifetime, of individual molecules that inform on environmental conditions, whilst avoiding the artefacts of ensemble averaging. Protein interactions, molecular dynamics and sub-species can all be studied. In a burst integrated fluorescence lifetime (BIFL) experiment, identification of fluorescent bursts from single molecules above background detection is a problem. This paper presents a Bayesian method for… CONTINUE READING

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